How can anticholinergic drugs affect body temperature regulation?

Anticholinergic drugs can impair the body's ability to sweat due to their mechanism of action, which involves blocking the effects of acetylcholine on muscarinic receptors. These receptors are crucial for stimulating sweat glands, which play a key role in thermoregulation by allowing the body to dissipate heat through the process of sweating. When sweating is reduced or inhibited, the body's natural cooling mechanism is compromised, leading to an increased risk of overheating, especially in hot environments or during vigorous physical activity. Thus, the correct answer highlights a significant effect of anticholinergic agents on body temperature regulation by pointing out their role in hindering the sweating response.