How do anticholinergic agents affect vaginal dryness?

Anticholinergic agents exert their effects by blocking the action of acetylcholine, a neurotransmitter that plays a crucial role in the stimulation of many bodily functions, including secretions in various mucosal tissues. When acetylcholine's action is inhibited, the result is a reduction in secretions in areas such as the respiratory system and gastrointestinal tract, as well as the vaginal mucosa. Consequently, this inhibition leads to decreased moisture and lubrication in the vaginal area, which can contribute to vaginal dryness.

Therefore, anticholinergic agents exacerbate this condition by further reducing the natural lubrication that is necessary for maintaining moisture in the vaginal tissues. Understanding this mechanism can help in addressing side effects associated with the use of these medications, especially in women who may already experience vaginal dryness due to other factors.