True or False: At low doses, antagonist (nondepolarizing) neuromuscular blockers can be reversed by AChE inhibitors.

At low doses, antagonist (nondepolarizing) neuromuscular blockers can indeed be reversed by acetylcholinesterase (AChE) inhibitors. Nondepolarizing neuromuscular blockers work by competitively inhibiting the action of acetylcholine at the neuromuscular junction, which prevents muscle contraction. When these blockers are administered in lower doses, there is still some degree of neuromuscular transmission occurring.

By using AChE inhibitors, such as neostigmine or edrophonium, the levels of acetylcholine in the synaptic cleft can be increased because the enzyme acetylcholinesterase, which normally breaks down acetylcholine, is inhibited. This increase in acetylcholine can compete with the neuromuscular blocker at the receptor sites, effectively reversing the effects of the blocker.

This method of reversal is most effective at lower doses of the antagonist because higher doses may result in significant receptor blockade that cannot be overcome simply by increasing acetylcholine concentration due to saturation of the receptors. Therefore, the statement is true, as AChE inhibitors can effectively reverse the effects of low doses of nondepolarizing neuromuscular blockers.