What is a lesser-known application of anticholinergic drugs in dermatology?

Anticholinergic drugs are used in dermatology for a variety of purposes, one of which includes the reduction of excessive sweating, a condition known as hyperhidrosis. This application is less well-known compared to their more common uses, such as in the treatment of respiratory conditions or gastrointestinal disorders.

The mechanism by which anticholinergic agents reduce sweating involves the blockade of acetylcholine receptors at eccrine sweat glands, which inhibits the secretion of sweat. This makes them particularly useful for individuals who experience excessive sweating in specific areas, such as the palms, soles, or underarms. Treatments may include topical formulations, such as glycopyrrolate, or systemic medications.

While anticholinergic drugs can influence various dermatological conditions, their role in managing excessive sweating stands out as a notable lesser-known application that provides significant relief for those afflicted by this condition. Other conditions such as psoriasis, eczema, and dermal wounds typically do not benefit from anticholinergic therapy, as their pathophysiology and treatment mechanisms differ substantially.