What should be monitored in patients receiving high doses of anticholinergic agents chronically?

High doses of anticholinergic agents administered chronically can lead to several adverse effects, particularly on cognitive function. Anticholinergic agents block the action of acetylcholine, a neurotransmitter essential for many functions in the central nervous system, including memory and cognitive processes. Chronic use of these medications has been associated with increased risks of cognitive decline, confusion, and delirium, particularly in elderly populations who may be more sensitive to these effects.

Monitoring cognitive function and signs of delirium is crucial because these adverse effects can significantly impair a patient’s quality of life and can lead to further complications or the need for additional medical interventions. Therefore, ensuring proper assessment and monitoring of cognitive status can help identify early signs of these adverse effects, allowing for timely intervention.

On the other hand, while monitoring blood pressure, electrolyte balance, and liver enzymes can be important in certain contexts, they are not as directly relevant to the chronic administration of high doses of anticholinergic agents when it comes to assessing cognitive and neurological impacts.