Which cardiovascular effect is commonly associated with Succinylcholine administration?

Succinylcholine is a depolarizing neuromuscular blocker commonly used in anesthesia to facilitate rapid intubation and muscle relaxation. One of the cardiovascular effects associated with its administration is a decrease in heart rate. This occurs due to the drug's action in stimulating the autonomic ganglia, specifically the parasympathetic nervous system. The stimulation of the vagus nerve by succinylcholine can lead to increased vagal tone, resulting in bradycardia, which is characterized by a reduced heart rate. This is particularly notable during the initial phase of succinylcholine administration, often referred to as "phase I block," when the drug acts as an agonist at the neuromuscular junction and can also have effects on autonomic control of the heart.

Understanding the cardiovascular implications of succinylcholine is crucial for clinical practice, as clinicians need to monitor heart rate and be prepared to manage possible bradycardia, especially in patients who are more sensitive to vagal stimulation.