Which of the following adverse drug events is associated with high doses (10 mg) of atropine?

High doses of atropine, particularly around 10 mg, are associated with central nervous system effects, including restlessness and hallucinations. Atropine is an anticholinergic agent that blocks the action of acetylcholine on muscarinic receptors. While at lower doses, atropine primarily exerts peripheral effects, higher doses increase the likelihood of central effects due to its ability to cross the blood-brain barrier.

This increased central activity can lead to symptoms such as confusion, agitation, restlessness, and visual or auditory hallucinations. The effects can be more pronounced in susceptible populations, such as the elderly. At lower doses or in therapeutic ranges, atropine may lead to effects like dry mouth or decreased secretions, which pertain more to its anticholinergic properties rather than CNS effects. The emphasis on the CNS effects at high doses distinguishes this adverse event from typical peripheral side effects.