Which of the following agents can be reversed by AChE inhibitors?

The correct choice indicates that non-depolarizing neuromuscular blockers can be reversed by acetylcholinesterase (AChE) inhibitors. Non-depolarizing neuromuscular blockers work by competitively inhibiting the binding of acetylcholine to nicotinic receptors at the neuromuscular junction, leading to muscle paralysis without causing depolarization of the motor end plate.

AChE inhibitors, such as neostigmine, increase the concentration of acetylcholine in the synaptic cleft by inhibiting the enzyme that breaks it down. This increased availability of acetylcholine can compete with the non-depolarizing blockers for binding to the receptors, thereby overcoming the paralysis.

In contrast, depolarizing neuromuscular blockers, such as succinylcholine, act by causing a prolonged depolarization of the motor end plate, which leads to initial muscle contraction followed by paralysis due to desensitization of the receptors. AChE inhibitors do not effectively reverse the effects of depolarizing agents because the mechanism of action is fundamentally different; they do not merely block receptor availability but rather cause a persistent activation of the receptors. Therefore, while AChE inhibitors can restore neuromuscular function affected by