Which treatment can be used to reduce excessive sweating (hyperhidrosis) in a manner similar to anticholinergic agents?

Botulinum toxin injections are effective in reducing excessive sweating, or hyperhidrosis, by inhibiting the release of acetylcholine at the neuromuscular junction, which is a mechanism that is similar to that of anticholinergic agents. When botulinum toxin is injected into the areas of excessive sweating, it blocks the signals that activate sweat glands, thereby reducing sweat production.

This method is particularly beneficial for patients who have not had success with other treatments for hyperhidrosis. The effects of the injections can last several months, making it a practical and effective option for managing this condition.

The other treatments listed do not directly address the underlying mechanism by which excessive sweating occurs. Oral antihistamines typically deal with allergic reactions, selective serotonin reuptake inhibitors are primarily used for depression and anxiety, and topical corticosteroids are used for inflammatory skin conditions. None of these alternatives have a significant impact on sweat gland activity like botulinum toxin does.